BIOPHARMACEUTICAL POTENTIAL OF AMINOPHOSPHONATES BASED ON MORPHOLINOETHYLAMINE

Abstract

Abstract. Morpholine derivatives play an important role in modern pharmaceutics due to their wide
spectrum of biological activity. In this regard, the aim of this study is to investigate the properties of new
synthesized aminophosphonates based on morpholinoethylamine, including the study of their biological
activity. Aminophosphonates were synthesized by the Kabachnik-Fields reaction, purified and
characterized using IR and NMR spectroscopy. Biological activity was studied in vitro and in vivo:
myelostimulating effect on laboratory rats and the effect on plant growth during the treatment of wheat
seeds were assessed. In addition, the possibility of obtaining ionic liquids based on these compounds was
assessed using quantum chemical calculations. One of the compounds increased platelet indices, which
may indicate its potential as a stimulator of thrombocytopoiesis. Two of the three compounds activated
plant growth, exceeding the control samples. Quantum chemical calculations confirmed the possibility of
obtaining ionic liquids, opening up prospects for further study. The obtained compounds can find
application in medicine (in particular, in stimulating thrombocytopoiesis) and agriculture (as plant growth
stimulants).