SYNTHESIS AND PHARMACOLOGY OF THE NEW ANTIMICROBIAL DRUG AIP-10

Abstract

In present research, amide adamantanecarboxylic acid was synthesized according to the Schotten-Bauman by the method acylation of thiomorpholine with adamantanecarbonyl chloride, in order to obtain a pharmacologically acceptable form, the drug AIP-10 was synthesized in combination with β-cyclodextrin, which showed antimicrobial and fungicidal activity in the practice of in vitro. The reaction was carried out in absolute benzene with cooling and the ratio amine: acylating agent = 2: 1. The composition and structure of the synthesized compounds were confirmed by elemental analysis and IR, NMR spectroscopy, individuality - by thin-layer chromategraphy.

References

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