SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF FLUOROBENZOIC ACID AMIDES

Abstract

In the framework of this study, amides of fluorobenzoic acids were synthesized by acylation of piperidine with para-, meta-, ortho-fluorobenzoyl chlorides according to Schotten-Baumann, which showed pronounced antimicrobial activity in the in vitro experiment. The reaction was carried out in absolute benzene with cooling and the ratio amine: acylating agent = 2: 1. The composition and structure of the synthesized compounds were confirmed by elemental analysis and IR, NMR spectroscopy, individuality – by thin-layer chromate-graphy.

References

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