OXIDATION OF 4-METHYLPYRIDINE ON V-Cr-O CATALYST

Abstract

Isonicotinic acid derivatives are used in the development of new antibacterial agents, active ingredients in pesticides and herbicides. In addition, isonicotinic acid is a precursor for the synthesis of isoniazid, one of the most effective anti-TB drugs. Considering the importance of isoniazid in the treatment of tuberculosis, improving methods of synthesizing isonicotinic acid has a direct impact on the availability and cost of this life-saving drug. The goal of this work was to investigate the efficiency of V-Cr-O catalyst in the oxidation of 4-methylpyridine to produce isonicotinic acid, to study its composition and properties. Research methods. Methods of chemical analysis, scanning electron microscope (SEM), Raman spectroscopy were applied. Results and Discussion. In this work, the processes of isonicotinic acid synthesis by oxidation of 4-methylpyridine on the V-Cr-O catalyst were studied. Analysis of the obtained results showed that with an increase in the water feed, there is a general tendency towards a decrease in the conversion of 4-methylpyridine at all temperatures. For example, at a temperature 300^oC, the degree of conversion drops from 91.72% at 1.79 g/h to 84.20% at 6.6 g/h. The yield of isonicotinic acid increases as the amount of water rises, reaching its peak at 47.46% with a temperature of 360°C and a water supply of 6.6 g/h. In contrast, the minimum yield is only 15.27% at 280°C with a water supply of 1.79 g/h. This highlights the positive correlation between water supply and yield, especially at higher temperatures.