BIOLOGICAL ACTIVITY OF SOME ACETYLENE AMINO-ALCOHOLS AND HALOIDAMMONIUM SALTS ON THEIR BASIS

Abstract

The biological activity of substituted aminopentinols, aminohexinols and some of their derivatives was studied. It was found that acetylene amino alcohols and most of their ammonium salts have biological activity and, depending on the chemical structure and doses, have different biological effects with respect to the cultures used. The authors used a well-known method-biotesting on wheat coleoptiles-to detect the biological activity of the studied drugs

References

[1] Application: 2001120265/04, 07.23.2001. A01N31 / 04, C07C33 / 042. Plant growth regulator / Schelkunov S, A., Malyshev O.A. Bulletin number and year of publication: 21-2004.

[2] Patent Russia, No. 2155759. 2000. Acetylene-type amino alcohols with pronounced M-anticholinergic properties and weakly inhibit the central nervous system / Libman N.M., Zatsepin E.P., Pashkevich B.P.

[3] Azerbaev I.N. et al. // Vestn. Academy of Sciences of the Kazakh SSR. 1964. No. 4. P. 60.

[4] Schwechheimer G.A. A new way of synthesis of diethylaminomethyl derivatives of substituted propargyl alcohols // Izv. USSR Academy of Sciences. OKN. 1957. No. 10. P. 1265-1266.

[5] Liebman N.M., Kuznetsov S.G. Amino alcohols-acetylene feed. I. Preparation of 1,1-disubstituted 4-dialkylaminobutin-2-tin-1 // Zhokh. 1960. Vol. 30, No. 4. P. 1197-1202.

[6] Azerbaev I.N., Makanov U., Kasymkhanova R.F., Antonov V.N., Omarova T.A. Ester derivatives of acetylene aminocarbinols // Izv. AN KazSSR Ser. Chem. 1969. No. 5. P. 82-85.

[7] Kurbanov F.K., Kuchkarov A.B., Kurbanov S.Sh. // Izv. universities. Chemistry and Chem. technology. 1974. Vol. 17, No. 10. P. 1584.

[8] Boyarkin M.Ya. // Dokl. USSR Academy of Sciences. 1948. No. 9(59). P. 1651.

[9] Kefeli V.I. et al. In the book: Methods for the determination of phytohormones, growth inhibitors, defoliants and herbicides. M.: Nauka, 1973. P. 7.

[10] Turgunov E. Research of synthesis processes and properties of acetylene heterocyclic amino derivatives and products based on them: Dis. … k.kh.s. Tashkent, 1990. 210 p.

[11] Turgunov E., Yuldashev A., Sadikov M.K. Quaternary ammonium salts of acetylene amines // Reports of the Academy of Sciences of the Republic of Uzbekistan. 2010. No. 2. P. 64-67.

[12] Turgunov E., Suleymanova G.G., Sobirova D.K., Hudoyberdieva Z., Кolyadin V.G., Faizullaeva M. Herbicide activity of acetylenicaminoalcohols and their ammonium bases // European Sciences review. Scientific journal. 2016. № 3–4 (March–April). P. 317-320.