POTENTIAL OF IMIDAZOLE-CONTAINING DERIVATIVES FOR PRACTICAL APPLICATION (Review)

Abstract

Introduction. The imidazole ring is becoming a popular structural fragment in synthetic
pharmaceuticals, being an ionizing and aromatic component, which activates pharmacokinetic properties.
The imidazole cycle is present in many antiprototic, antifungal and antihypertensive drugs, antibiotics and
others. These structures are effective against various strains of microorganisms. The imidazole block is
contained in the anticancer drug mercaptopurine, which has an effect by interfering with the DNA activity
in the treatment of leukemia. Purpose: to review imidazole derivatives with various types of physiological
and/or other actions published in the scientific literature over the last twenty years. Objects of research:
imidazole derivatives. Results.An imidazole fragment is contained in a large number of natural products
and clinically active drug molecules. Most of the publications relate to the study of the therapeutic
possibilities of new structures of the class of imidazole derivatives for medical use. However, the potential
of imidazole-containing molecules is not limited only to BAS, their other properties are interesting, in
particular such one as corrosion inhibition. Conclusion: The introduction of a highly active imidazole
fragment into an organic molecule stimulated the appearance of notable achievements in the field of
chemotherapeutic and antibacterial agents. The active synthetic search for highly active imidazole
compounds continues not only in the field of biologically active compounds, but also as the potential
anticorrosiveand other agents.