STUDY OF THE ANALGESIC ACTIVITY OF(S)-1-METHYL-3-(1-(5-PHENYL ISOXAZOLE-3-CARBONYL) PIPERIDINE-2-IL) PYRIDINE-1-IUM IODIDE
Keywords:Alkaloid, anabazine, synthesis, phenylisoxazole, combined derivatives, pharmacology, biological activity, drug, analgesic activity, chromatography
Introduction. Recently, the attention of specialists to medicines of natural origin has been constantly growing. The interest in the use of such drugs obtained from natural raw materials is justified by high efficiency, a wide range of pharmacological activity, as well as the possibility of using them for a long time without complications and side effects. The share and volume of production of medicinal products is increasing all over the world, through synthetic transformations of substances isolated from wild and cultivated plants. Substances of plant origin are widely used as biologically active additives, agrochemical agents. Research in the field of modern chemistry of plant substances in the Republic and abroad is devoted to a comprehensive and comprehensive study of plant raw materials, including the extraction and designation of the structure and chemical properties of plant components, the study of their biological activity, the development of effective and environmentally safe methods for complex processing of plant raw materials. The attractiveness of alkaloid derivatives to compounds is due to the versatility of their reactivity, as well as the practical use of alkaloid derivatives as medicines. Modification of the molecules of natural compounds by introducing such a substituent is one of the promising directions in the search for new biologically active compounds. Analysis of the results of analgesic activity assessment experiments showed that(s)-1-methyl-3-(1-(5-phenylisoxazole-3-carbonyl) piperidine-22 Il) pyridine-2-Il) pyridine-1-IUM iodide has the ability to reduce the severity of specific nociceptive responses in rats during chemical irritation of the peritoneum. The analgesic activity of the test sample was analyzed on diclofenac sodium.