DETERMINATION OF THE CHEMICAL COMPOSITION OF COUSINIA MINDSCHELKENSIS B. FEDTSCH. BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHOD

Abstract

Introduction.   Vegetation is important component and factor of the redistribution of chemical elements in the landscape. One or another type of vegetation determines the amount and nature of soil organic matter, often affects the degree of development of browning processes, affects the chemical composition of the air, is an environmental indicator.  The study and isolation of physiologically active compounds from plant raw materials and the determination of the place of their demand is the most important urgent task. Cousinia mindschelkensis B. Fedtsch. It is a rare species from the Asteraceae. Methods. In the Research Center of Medicinal Plants of the Al-Farabi KazNU, analyses were carried out for the determination of organic compounds by gas chromatography with mass spectrometric detection and analyses of 70% of alcohol extracts of the aboveground and underground parts species by the method of high-performance liquid chromatography on a liquid chromatograph. Results. Some of the components identified by GC-MS are biologically active compounds. The GC-MS method revealed the presence of 55 phytochemical compounds in the aboveground and 38 in the underground part of plants that can contribute to the medicinal properties of this species. Conclusion. Compounds have some important biological potential for future drug development. Of the aboveground part of the plant includes bicyclo[2.2.1]heptan-2-one, 1.7.7-trimethyl-, (1S)- (9.50%), hexadecanoic acid (8.05%), cis-Vaccenic acid (7.66%), 9.12-Octadecadienoic acid (Z,Z)- (7.40%), hanphyllin (7.01%), 5.8-Dihydroxy-4a-methyl-4,4a,4b,5,6,7,8,8 a,9,10-decahydro-2(3H)-phenanthrenone (6.51%), dibutyl phthalate (5.64%), while the underground part of the plant has a spike of components such as octacosane (26.84%), β-amyrin (22.35%), β-sitosterol (12.63%), 9.12-Octadecadienoic acid (Z,Z)- (8.43%).9,12-Octadecadienoic acid (Z,Z)-  it is present both in the aboveground (7.40%) and in the underground part of the plant (8.43%).