Kharlamova T.V. ANTI-FUNGAL ACTIVITY OF ANTHRAQUINONE DERIVATIVES (Part 2)
Abstract
Introduction. Fungal infections are an increasingly recognized global threat to human, animal and plant health. The problem is acute in agriculture as well. The problems posed by fungal plant pathogens affect global food security by causing severe damage to many valuable crops. This is related to crop yields, post-harvest losses, and contamination of forage and consumer products.
The purpose of this review paper is to present information on the current state of plant fungal diseases and the search for new antifungal structures among natural compounds, in particular anthraquinone derivatives. Objects. Derivatives of 9,10-anthraquinone: chrysophanol, emodin, рhyscion, rhein, aloe-emodin. Results. Fungi are key components of global biogeochemical cycles and include numerous species with pathogenic potential that affect various plant species. Of particular concern is the impact of fungal pathogens on cultivated and commercial plant species on which the food security of the world population depends. Among natural compounds, 9,10-anthraquinone derivatives represent a group of quinones with biological activity and great structural diversity. This review presents the data on the main fungal plant pathogens and the analysis of the antifungal activity of the most abundant anthraquinone molecules, such as chrysophanol, emodin, physcion, rein and aloe-emodin, as well as some structurally related molecules, in order to analyze the influence of chemical structure of derivatives on their activity. Conclusion. Natural sources of antimicrobial agents, which can be regarded as an alternative to traditionally used drugs, have now begun to receive special attention. Natural sites contain a variety of biologically active secondary metabolites. Among them, derivatives of 9,10-anthraquinone, such as chrysophanol, emodin, physcion, rein, aloe-emodin, have shown activity against a variety of plant fungal pathogens and can be considered as promising structures for finding new antifungal agents.
