LEUKOPOIESIS- AND IMMUNO-STIMULATING PROPERTIES OF COMPLEX OF O-BENZOYLOXIME OF 3-(3-ETHOXYPROPYL)-7-[2-(PIPERAZIN-1-YL)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE WITH β-CYCLODEXTRIN
PDF (Русский)

Keywords

O-benzoyloxime of 3-(3-ethoxypropyl)-7-[2-(piperazin-1-yl)ethyl]-3
3,7-diazabicyclo[3.3.1]nonan-9-one
complex with β-cyclodextrin
leukopoiesis- and immuno- stimulating properties

Abstract

Leucopoiesis- and immuno- stimulating effects of the complex of O-ben-zoyloxime of 3-(3-ethoxypropyl)-7-[2-(piperazin-1-yl)ethyl]-3,7-diazabicyclo[3.3.1]-nonan-9-one with β-cyclodextrin under the laboratory code BIV-104 had been studied. It had been found that BIV-104 has a unique leucopoiesis stimulating activity. Most of the studied blood counts of experimental rats that were injected BIV-104 exceeded those of the control group: total leukocyte - almost 4 times (p≤0.01), absolute granulocyte - 5.59 times. The absolute values of lymphocytes increased by 3.37 times compared with this blood indicator of the control group. Absolute monocytic levels were also higher in the BIV-104 injection group, being (0.48±0.01)⋅109/L of blood against (0.26±0.17)⋅109/L of ones. The erythrocyte count exceeded 1.5 times, the hemoglobin level was 1.57 times higher, the total platelet count was 2.01 times that of the control group. BIV-104 equally effectively stimulated the proliferative activity of myeloid and lymphoid germ.

References

[1] Omarov T.T., Bajsalbaeva S.A., Gubasheva A.Sh. Sintez i prevrashhenija ketonov 3-aza-, 3,7-diazabiciklo[3.3.1]nonanovogo i 1,3-diazaadamantanovogo rjadov // V sb.: Prirodnye i sinteticheskie biologicheski aktivnye veshhestva. Alma-Ata, 1980. Vol. 52. P. 147-170.

[2] Omarov T.T., Gubasheva A.Sh. Konformacionnye jeffekty u proizvodnyh 2,4-difenil-3-azabiciklo[3.3.1]nonan-9-ona // Vest. AN KazSSR. 1983. № 8. P. 68-72.

[3] Omarov T.T., Zaporozhskaja N.I. Sintez 2,4-difenil-3-azabiciklo [3.3.1]non-2-en-9-ola // Zh. organ. himii. 1985. Vol. 21, № 2. P. 461-462.

[4] Innovacionnyj patent № 31026. Kompleks O-benzoiloksima 3-(3-jetoksipropil)-7-[2-(piperazin-1-il)-jetil]-3,7-diazabiciklo[3.3.1]nonan-9-ona c β-ciklodekstrinom, obladajushhij mest-noanestezirujushhej aktivnost'ju / Pichhadze G.M., Praliev K.D., Smagulova G.S., Iskakova T.K., Malmakova A.E., Kadyrova D.M., Raimkulova K.B.; bjul. № 4, 2016.

[5] Malmakova A.E., Ju V K., Praliev K.D., Amirkulova M.K. Sintez i mestnoaneste-zirujushhaja aktivnost' kompleksa O-benzoiloksima 3-(3-jetok-sipropil)-7-[2-(piperazin-1-il)jetil]-3,7-diazabiciklo[3.3.1]nonan-9-ona s β-ciklodekstrinom // Mezhdunarodnoj nauchno-prakticheskoj konferencii «Aktual'nye problemy estestvoznanija i estestvennonauchnogo obrazovanija», posvja-shhennoj pamjati uchenogo-pedagoga, kandidata himicheskih nauk, docenta T.D. Kuanyshbaeva (1952‒1998 gg.), 7-8 nojabrja 2019 g., g. Kyzylorda. P. 99-103.

[6] Praliyev K.D., Welch J.T., Iskakova T.K., Ibraeva S.S. Synthesis of novel 3,7-diaza-bicyclo[3.3.1]nonane derivatives // Eurasian Chemico-Technologocal Journal. 2014. Vol. 16, № 1. P. 85-89.

[7] Patent na poleznuju model' №2413. Primenenie kompleksa O-ben-zoiloksima 3-(3-jetoksipropil)-7-[2-(piperazin-1-il)jetil]-3,7-diazabicik-lo[3.3.1]nonana c b-ciklodekstrinom, v kachestve lejkopojezstimulirujushhego iimmunostimulirujushhego sredstva / Praliev K.D., Iskakova T.K., Malmakova A.E., Baktybaeva L.K., Ju V.K.; bjul. № 19, 16.10.2017, 5 p.

[8] Mashkovskij M.D. Lekarstvennye sredstva. M.: Medicina, 1986. Vol. 2. P. 169-170.

[9] Dyakonova V.A., Dambaeva S.V., Pinegin B.V., Khaitov R.M. Study of interaction between the polyoxidonium immunomodulator and the human immune system cells // International Immunopharmacology. 2004. Vol. 4, Issue 13. P. 1615-1623.

[10] Alexia C., Cren M., Louis-Plence P., Vo D.N., El Ahmadi Y., Dufourcq-Lopez E., Lu Z.Y., Hernandez J., Shamilov F., Chernysheva O., Vasilieva M., Vorotnikov I., Vishnevskay Y., Tupitsyn N., Rossi J.F., Villalba M. Polyoxidonium activates cytotoxic lymphocyte responses through dendritic cell maturation: clinical effects in breast cancer // Front. Immunol. 2019 Nov. 28; 10:2693. doi: 10.3389/fimmu.2019.02693.

[11] Chernikova M.I., Kashirina O.S., Vasiliev Y.M. Comparative immunogenicity studies of adjuvants from various sources and with different mechanisms of action for inactivated influenza vaccines // Zh. Mikrobiol. Epidemiol. Immunobiol. 2015 Nov.-Dec.; (6): 63-71 (in Russ.).

PDF (Русский)