LEUKOPOIESIS- AND IMMUNO-STIMULATING PROPERTIES OF COMPLEX OF O-BENZOYLOXIME OF 3-(3-ETHOXYPROPYL)-7-[2-(PIPERAZIN-1-YL)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE WITH β-CYCLODEXTRIN

Abstract

Leucopoiesis- and immuno- stimulating effects of the complex of O-ben-zoyloxime of 3-(3-ethoxypropyl)-7-[2-(piperazin-1-yl)ethyl]-3,7-diazabicyclo[3.3.1]-nonan-9-one with β-cyclodextrin under the laboratory code BIV-104 had been studied. It had been found that BIV-104 has a unique leucopoiesis stimulating activity. Most of the studied blood counts of experimental rats that were injected BIV-104 exceeded those of the control group: total leukocyte - almost 4 times (p≤0.01), absolute granulocyte - 5.59 times. The absolute values of lymphocytes increased by 3.37 times compared with this blood indicator of the control group. Absolute monocytic levels were also higher in the BIV-104 injection group, being (0.48±0.01)⋅109/L of blood against (0.26±0.17)⋅109/L of ones. The erythrocyte count exceeded 1.5 times, the hemoglobin level was 1.57 times higher, the total platelet count was 2.01 times that of the control group. BIV-104 equally effectively stimulated the proliferative activity of myeloid and lymphoid germ.

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