SYNTHESIS OF BIOLOGICALLY ACTIVE AMIDES OF ADAMANTAN CARBOXYLIC ACID
Keywords:
amides, adamantanecarbonyl chloride, piperidine, morpholine, thiomorpholine, phenylpiperazine, diphenylmethyl piperazineAbstract
Within of this study, amides of adamantanecarboxylic acid were synthesized by acylation of a number of cyclic amines: piperidine, morpholine, phenylpiperazine and diphenylmethyl piperazine under the conditions of the Schotten-Baumann reaction. The reaction was carried out in absolute benzene with cooling and the ratio amine: acylating agent = 2: 1. The composition and structure of the synthesized compounds were confirmed by elemental analysis and IR, NMR spectroscopy, individuality - by thin-layer chromatography.
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