RELEASE OF ANESTHETIC DRUGS FROM HYDROGEL BASED ON POLYHYDROXYETHYLMETHACRYLATE

Authors

  • Е. О. Batyrbekov A.B. Bekturov Institute of chemical sciences
  • T. K. Jumadilov A.B. Bekturov Institute of chemical sciences
  • M. B. Umerzakova A.B. Bekturov Institute of chemical sciences
  • А. E. Borisova Kazakh-British Technical University

Keywords:

release, polymeric hydrogel, polyhydroxyethylmethacrylate, lidocaine, novocaine

Abstract

The release of anesthetic drugs from polymeric hydrogel based on polyhydroxyethylmethacrylate has been studied. The influence of various factors on process of release drugs from polymeric hydrogels was described. Anesthetic, evenly dissolved in polymeric matrix, was released in model media by the mechanism of diffusion with rate reduction.

References

[1] Peppas N.A. ed. Hydrogels in medicine and Pharmacy. CRC Press, Boca Raton: Fl, 1987. 182 p.
[2] Wichterle O., Lim D. Hydrophilic gels for biological use // Nature. 1986. Vol. 185. P. 117-118.
[3] Kinam P., Shalaby S.W., Haesun P. Biodegradable Hydrogels for Drug Delivery. Technomic Publ., 1993. 252 p.
[4] Mack E.J., Okano T., Kim S.W. Biomedical application of poly-(2- hydroxyethylme-thacrylate) and its copolymers // Hydrogels in medicine and pharmacy. – CRC Press, Boca Raton: Fl., 1987. Vol. 2. P. 65-93.

Downloads

Published

2021-05-03

Issue

№ 4 (2018): Chemical Journal of Kazakhstan

Section

Articles