SYNTHESIS OF NEW DERIVATIVES OF PHENYLOXYPROPARGYL PIPERIDINES

Authors

  • G. S. Akhmetova A.B. Bekturov Institute of chemical sciences
  • U. B. Issayeva A.B. Bekturov Institute of chemical sciences
  • K. D. Praliyev A.B. Bekturov Institute of chemical sciences
  • N. V. Korotetskaya Scientific Center of Antimicrobial Preparations
  • О. Т. Seilkhanov Sh. Ualikhanov Kokshetau State University

Keywords:

phenoxypropargylpiperidine-4-ol, cyclobutane-, cyclopentane-, cyclohexanecarbonyl chlorides, esters

Abstract

4-(3-phenoxyprop-1-yn-1-yl)piperidine-4-ol has been obtained by condensation of 1-methyl-piperidine-4-one with phenoxypropargyl in the Favorsky reaction conditions in absolute benzene, in the presence of a fivefold excess of powdered technical KOH at the ratio of piperidone-4:phenoxypropargyl = 1:1.5. Upon acylation of tertiary phenoxypropynyl piperidol by cyclobutane-, cyclopentane-, cyclohexanecarbonyl chlorides in dioxane at the room temperature or upon heating, the corresponding hydrochlorides of esters have been formed. The structure of the synthesized compounds has been confirmed by the NMR and X-ray spectroscopy data.

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Published

2021-05-03