IN VITRO ANTI-TUBERCULOSIS AND ANTI-DIABETIC ACTIVITY OF O-TOSYLATES-β-AMINOPROPIOAMIDOXIMES AND CHLORIDES OF 2-(HETEROAMINO)-1,5-DIAZOSPIRO[4,5]DECANE-1-EN-5-AMMONIUMS
Keywords:
O-tosylates-β-aminopropioamidoximes, chlorides of 2-amino-4,5-dihydrospyropyrazolylammoniums, in vitro anti-tuberculosis and anti-diabetic activityAbstract
O-Tosylates-β-aminopropioamidoximes and chlorides of 2-amino-4,5-dihydrospyropyrazolylammoniums have been studied in vitro for anti-tuberculosis and anti-diabetic activity. In two groups of compounds containing β-amino groups: piperidin-1-yl, morpholin-1-yl, thiomorpholin-1-yl, 4-phenylpiperazine-1-yl, benzimidazol-1-yl (with the exception of the benzimidazole derivative in the spiro derivative series), drugs with an average anti-tuberculosis activity were detected on the DS strains of M. tuberculosis (MBC 50 μg/ml) and with moderate anti-diabetic α-amylase activity (27% to 29%) in the first row, containing β-amino groups: piperidin-1-yl, morpholin-1-yl and in the second row – piperidin-1-yl.
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