ESTERS OF CYCLOPROPANECARBOXYLIC ACID DISPLAYING ANTI-INFECTIVE ACTIVITY

Abstract

A number of esters of cyclopropanecarboxylic acid of N-alkyl naphthyloxypropynylpiperidines antimicrobial activity have been studied in relation to the archival strains of microorganisms. The activities of the given preparations have been assessed in vitro in relation to Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Salmonella enterica ATCC 14028 and Staphylococcus aureus ATCC 6538-P, among which hydrochloride of 1-methyl-4-[3-(naphth-1-yloxy)prop-1-in-1-yl]-4-cyclopropanecarbonyloxypiperidine has displayed the greatest activity in relation to the archival strain of Bacillus subtilis ATCC 6633 in the concentration of 250 μg/ml. Esters of cyclopropanecarboxylic acid of N-methyl phenoxypropynylpiperidine and phenyl ethinylpiperidine have displayed antimicrobial activity in vitro in relation to all seven strains of microorganisms, used in the experiment: Escherichia coli ATCC 25922, Escherichia coli ATCC-BAA-196, Klebsiella pneumoniae ATCC 10031, Klebsiella pneumoniae ATCC 700603, Staphylococcus aureus ATCC 6538-P, Staphylococcus aureus ATCC-BAA-39, Candida albicans ATCC 10231. Hydrochloride of ester of N-benzylpiperidine-4-ketoxime of cyclopropanecarboxylic acid has a bactericidal activity in relation to the strains of the testing cultures of Eshirichia Coli1257 and Staphylococcus aureus 209-Р.

References

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