FLUOROBENZOATES OF 1-PROPYL-4-KETOXIMEPIPERIDINE AS POTENCIAL LOCAL ANESTHETICS
Keywords:
p-fluoro-, m-fluoro-, o-fluorobenzoylcarbonylchloride, N-propylpiperidine-4-ketoxime, esters, 1-propyl-4-(p-fluoro-, m-fluoro-, o-fluorobenzoyloxyimino)piperidine, local anesthetic activityAbstract
p-Fluoro-, m-fluoro-, о-fluorobenzoates of 1-propyl-4-ketoximepiperidine, displaying a local anesthetic activity in varying degrees, have been synthesized. An introduction of fluorine leads to the formation of local anesthetics of different efficiency. Depending on the position of a fluorine atom in the phenyl ring, the greatest activity has been displayed by p-isomers, then o-isomers, whereas m-fluorobenzoates have proved to be less active.
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