RELEASE OF ANESTHETIC DRUGS FROM POLYMERIC FILMS
Keywords:
release, polymeric films, polyvinyl alcohol, lidocaine, periodont treatmentAbstract
The release of anesthetic drug from polymeric medicinal films with the prolonged therapeutic action is studied. Local anesthetic lidocaine is used as anesthetics agent. The films are obtained by watering of polyvinyl alcohol solution of different concentration on the horizontal glass surface with their subsequent drying during 2-3 days. Kinetics of drug release from films in model biological environments is investigated. Lidocain, evenly dissolved in polymeric matrix, is released by the mechanism of diffusion with rate reduction. The clinical tests of polymeric anesthetic films are conducted at treatment of periodontal pathology.
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