SYNTHESIS AND INVESTIGATION OF ALBUMIN NANOPARTICLES LOADED WITH ANTITUBERCULOSIS DRUG “P-AMINOSALICYLIC ACID”
Keywords:
polymeric nanoparticles, albumin, antituberculosis drug, p-aminosalicylic acid, adsorption, incorporationAbstract
In this work the possibility of binding antituberculosis drug p-aminosalicylic acid with the nanoparticles of serum albumin with the aim of increasing the therapeutic efficacy of the drug is studied. The results of the investigation of physicochemical characteristics of nanoparticles loaded with the drug obtained by adsorption and incorporation methods are shown. Drug release kinetics of p-aminosalicylic acid from polymeric matrix of albumin is studied. Optimal physicochemical characteristics of albumin nanoparticles loaded with the drug and high meanings of binding degree points on perspective of the use of nanosomal forms of antituberculosis drug “p-amino salicylic acid”.
References
[1] Du Toit L.C., Pillay V., Danckwerts M.P. Tuberculosis chemotherapy: current drug delivery approaches: Review // Respiratory Research. 2006. 7. 118. P. 1-18.
[2] Bui К.Т., Alyautdin R.N. Poli(laktidnye) nanochastitzy s sorbirovannymi protivotuberkulyeznymi sredstvami // Eksperimentalnaya i klinicheskaya farmakologiya. 2008. 3. P. 7-11.
[3] Kreuter. J. Colloidal Drug Delivery Systems. New York: Marcel Dekker, 1994. 344 p.
[4] Kratz F. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles // J. Cont. Rel. 2008. 132. P. 171-183.
[5] Weber C., Kreuter J., Langer K. Desolvation process and surface characteristics of HSAnanoparticles // Int. J. Pharm. 2000. 196. Р. 197-200.
[6] Langer K., Balthasar S., Vogel V., Dinauer N., Schubert von B. N. Optimization of the preparation process for human serum albumin (HSA) nanoparticles // Int. J. Pharm. 2003. 257. Р. 169-180.
[7] Dreis S., Rothweiler F., Michaelis M., Cinatl Jr., Kreuter J., Langer K. Preparation, characterization and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles // Int. J. Pharm. 2007. 341. Р. 207-214.
[8] Kreuter. J., Burkeev M.Zh., Tazhbaev E.M., Kazhmuratova A.T., Zhumagalieva T.S., Zhaparova L.Zh. Synthesis and characterization of polymeric nanoparticles based on albumin // Bulletin of Karaganda University. 2016.
