FLUOROPHENYL-CONTAINING Α-AMINOPHOSPHONATES: SYNTHESIS AND STRUCTURE

Abstract

Novel α-aminophosphonates 1-3 were synthesized by the one-pot three component reaction of equimolar quantities of dimethylphosphite, diphenylmethylpiperazine and a carbonyl component (4, 3 or 2-fluorobenzaldehyde) in benzene at reflux conditionsfor 30 h viaKabachnik-Fields reaction in high yields (82.9-90.3%). The progress of the reaction was monitored by thin layer chromatography analysis. The chemical structures were established by the physico-chemical methods as IR, 1H, 13C NMR and elemental analyses.

References

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