3,5-BIS(ARYLIDENE)PIPERIDIN-4-ONES AS SYNTHETIC CURCUMIN ANALOGUES

Abstract

The synthesis of divinyl ketones based on various cyclic ketones, in particular piperid-4-ones, with aromatic aldehydes is considered. The dependence of pharmacological activity on the nature of substituents in the aromatic ring and at nitrogen of the piperidine cycle is shown. The perspectivity of searching for anticancer drugs in a family of substituted 3,5-bis(arylidene)piperidin-4-ones has been established.

References

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