SYNTHESIS, STRUCTURE AND PASS PREDICTED BIOLOGICAL ACTIVITY OF 4-PHENYLNAPHTHOXYBUTYNYLPIPERAZINES

Abstract

New potentially biologically active 4-phenylnaphthoxybutynylpiperazines were synthesized. The structure of the synthesized compounds was established based on the IR and NMR (1H and 13С) spectroscopic data. A predicted biological activity of 4-phenylnaphthoxybutynylpiperazines was studied using the PASS program.

References

[1] https://ru.wikipedia.org/wiki/%D0%A6%D0%B8%D0%BF%D1%80%D0%BE%D1%84%D0%BB%D0%BE%D0%BA%D1%81%D0%B0%D1%86%D0%B8%
[2] Soldatenkov A.T., Kolyadina N.M., Shendrik I.V. Fundamentals of organic chemistry of medicinal substances. M.: Chemistry, 2001. 192 p.
[3] Severina A.I., Georgiyants V.А., Shtrygol S.Yu., Kavraiskyi D.P. Synthesis of N-substituted derivatives of 1-(4-methoxyphenyl)-1,5-dihydro-4Н-pyrazolo[3,4-d]pyrimidin-4-one as potential anticonvulsants // Scripta Scientifica Pharmaceutica. 2016. Vol. 3, N 2. P. 7-11.
[4] Triloknadh S., Venkata Rao Ch., Nagaraju K., HariKrishna N., Venkata Ramaiah Ch., Rajendra W., Trinath D., Suneetha Ye. Design, synthesis, neuroprotective, antibacterial activities and docking studies of novel thieno[2,3-d]pyrimidine-alkyne Mannich base and oxadiazole hybrids // Bioorganic & Medicinal Chemistry Letters. 2018. Vol. 28(9). P. 1663-1669.
[5] Rogoza L.N., Salakhutdinov N.F., Tolstikova G.A. Antituberculous activity of natural and synthetic compounds // Chemistry for Sustainable Development. 2010. Vol. 18. P. 343-375.
[6] Nisha, Kumar K., Bhargava G., Kirkwood M. Land, Chang Kai-H., Arora R., Sen S., Kumar V. N-Propargylatedisatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas Foetus // European Journal of Medicinal Chemistry. 2014. Vol. 74. P. 657-663.
[7] Kadutsky A.P., Ulaschik E.A., Kruglik A.S., Katin N.A., Shmanay V.V. Synthesis of the alkyne analogue of imatinib for conjugation with biomolecules // MedOrBioHim: International symposium. Crimea, 2014. P. 24.
[8] Sycheva Ye.S., Seylkhanov T.M., Vizer S.A., Yerzhanov K.B. Synthesis and structure 1,5-bis(aminobutyniloxy)naphthalines // Chemical journal of Kazakhstan. 2018. N 1. P. 120-127.
[9] Groult H., Leroux F., Tressaud A. Modern Synthesis Processes and Reactivity of Fluorinated Compounds: Progress in Fluorine Science. London: Academic Press, 2016. 760 p.
[10] Poroykov V.V., Filimonov D.A., Gloriozova T.A., Lagunin A.A., Druzhilovsky D.S., Stepanchikova A.V. Computer prediction of biological activity of chemical substances: virtual chemogenomics // Vavilovsky Journal of Genetics and Selection. 2009. Vol. 13(1). P. 137-143.