SYNTHESIS OF DITHIOACETYLENIC PIPERAZINE DERIVATIVES
Keywords:
one-pot synthesis, 1-methylpiperazine, 1-diphenylmethylpiperazine, carbon disulfide, dithioacetylenic derivativesAbstract
The conditions for the three-component one-pot synthesis of dithioacetylenic piperazine derivatives was developed. As a result prop-2-yn-1-yl-4-methylpiperazin1-carbodithioate (73,4%) and prop-2-yin-1-yl-4-diphenylmethyl piperazine-1-carbodithioate (93,6%) were synthesized. Structure of dithioacetylenic piperazine derivatives was established based on IR and NMR(1H and 13С) spectroscopic data.
References
[1] Bogdanov A.V., Vazykhova A.M., Khasiyatullina N.R., Krivolapov D.B., Dobrynin A.B., Voloshina A.D., Mironov V.F. New N-Mannich bases obtained from isatin and piperazine derivatives: The synthesis and evaluation of antimicrobial activity // Chemistry of Heterocyclic Compounds. 2016. Vol. 52, N 1. P. 25-30.
[2] Gein V.L., Syropyatov B.Y., Kasimova N.N., Dozmorova N.V., Voronina E.V., Vakh- rin M.I. Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-(2- piperazin-1-ylethyl)-2,5dihydropyrrol-2-ones and their derivatives // Pharmaceutical Chemistry Journal. 2013. Vol. 47, N 9. P. 485-489.
[3] Soboleva S.G., Galatin A.F., Karaseva T.L., Golturenko A.V., Andronati S.A. Synthesis and pharmacological properties of 1-aryl-4-(3′,4′,5′-trimethoxybenzoyl)piperazines // Pharmaceutical Chemistry Journal. 2005. Vol. 39, N 5. P. 236-238.
[4] Veselkina O.S., Solovtsova I.L., Petrishchev N.N., Galebskaya L.V., Borovitov M.E., Nilov D.I., Soloveva M.A., Vorobev E.A., Lenshina K.S. Influence of N,N′-Substituted Piperazines on Cytolysis // Pharmaceutical Chemistry Journal. 2016. Vol. 49, Issue 11. P. 743-748.
[5] Alka Bali, A. C. Dinesh Kumar. Reddy Synthesis and evaluation of meta substituted 1(aryloxypropyl)-4-(chloroaryl) piperazines as potential atypical antipsychotics // Medicinal Chemistry Research. 2013. Vol. 22, Issue 1. P. 382-391.
[6] Gergana M. Stoilkova, Petranka Yonova, Kalina Ananieva. Biological evaluation of newly synthesized aryl(thio)carbamoyl derivatives of 1- and 1-(2-aminoethyl)-piperazines // Plant Growth Regulation. 2014. Vol. 72, Issue 3. P. 303-312.
