PROLONGED RELEASE OF ANTICANCER DRUG CYTOXSANE FROM ALGINATE/CHITOSAN MICROPARTICLES

Abstract

Release of anticancer drug cytoxsane from alginate/chitosan microparticles has been studied. Modified microparticles were obtained in the following way: at the first stage sodium alginate was dissolved in distilled water at 2.5 wt.%. Cytoxsane as model antitumor drug was added to alginate solution and dissolved completely with stirring. The resulting solution was filtered and syringed dropwise into chitosan solution in calcium chloride at a constant dropping rate from the needle tip. As a result gel microparticles of calcium alginate were obtained, containing immobilized drug and a surface layer of chitosan. The release of cytoxsane from alginate gel particles into a physiological solution with different thickness of chitosan coating were studied. It was shown that the characteristic maximum on the curve of release observe after 120 min for the samples with the coating thickness 150 mcm. The data obtained shown a possibility of the regulation of the rate of cytoxsane release from the alginate/chitosan microparticles through thickness of the chitosan coating.

References

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