PROLONGED RELEASE OF ANTICANCER DRUG CYTOXSANE FROM ALGINATE/CHITOSAN MICROPARTICLES

Authors

  • E. O. BATYRBEKOV A.B. Bekturov Institute of chemical sciences
  • M. B. UMERZAKOVA A.B. Bekturov Institute of chemical sciences

Keywords:

release, cytoxsane, alginate, chitosan, microparticles

Abstract

Release of anticancer drug cytoxsane from alginate/chitosan microparticles has been studied. Modified microparticles were obtained in the following way: at the first stage sodium alginate was dissolved in distilled water at 2.5 wt.%. Cytoxsane as model antitumor drug was added to alginate solution and dissolved completely with stirring. The resulting solution was filtered and syringed dropwise into chitosan solution in calcium chloride at a constant dropping rate from the needle tip. As a result gel microparticles of calcium alginate were obtained, containing immobilized drug and a surface layer of chitosan. The release of cytoxsane from alginate gel particles into a physiological solution with different thickness of chitosan coating were studied. It was shown that the characteristic maximum on the curve of release observe after 120 min for the samples with the coating thickness 150 mcm. The data obtained shown a possibility of the regulation of the rate of cytoxsane release from the alginate/chitosan microparticles through thickness of the chitosan coating.

References

[1] Taghizadeh B., Taranejoo S., Monemian S.A., Salehi M.Z., Daliri K. Classification of stimuli-responsive polymers as anticancer drug delivery systems // Drug Delivery. – 2015. – No 2. – P. 145-155.
[2] De Souza R., Zahedi P., Allen C.J., Piquette-Miller M. Polymeric drug delivery systems for localized cancer chemotherapy // Drug Delivery. – 2010. – No. 6. – P.365-375.
[3] Sime W.J. Alginates // Food Gels. Ed. Harris P. Elsevier: London. – 1989. – P. 53–79.
[4] Azuma K., Osaki T., Minami S., Okamoto Y. Anticancer and anti-inflammatory properties of chitin and chitosan oligosaccharides // Journal of Funct. Biomater. – 2015. – No. 6. – P. 33-49.
[5] Lai F., Lin B., Mo F., Ch. Xu, Lin Xu. Novel Composite Microparticles of Alginate Coated with Chitosan for Controlled Release and Protection of Ascorbic Acid // Advances in Polymer Technology. – 2017. – Vol. 36, No. 1. – P. 58-67.
[6] Azevedo M.A., Bourbon A.I., Vicente A., Cerqueira M.Alginate/chitosan nanoparticles for encapsulation and controlled release of vitamin B2 // International Journal of Biological Macromolecules. – 2014. – Vol. 71. – P. 141-146.
[7] Batyrbekov E.O, Ismailova A.B., Baiyrkhanova A.O. Immobilization of fluorouracil on alginate microparticles // «Kahak» Review. – 2014. – No. 3(46). – P. 43-46.
[8] Batyrbekov E.O, Ismailova A.B., Baiyrkhanova A.O., Utelbaeva Z.T. Polymeric water soluble drug forms of fluorouracil based on polyvinylpyrrolidone // Chemical journal of Kazakhstan. – 2014. – No. 1. – P. 112-117.

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Published

2021-05-03